The Marquee Game: Florida (No. 21) vs Ole Miss (No. 4)

The highest-ranked matchup of the weekend puts the Rebels (3-0) on the road in Gainesville at 3:30 p.m. ET. Florida enters on a 52-3 win over Campbell and lands in the AP Top 25 for the first time this season, while Ole Miss arrives fresh off the signature victory over LSU.

The game turns partly on health: Rebels running back Kewan Lacy is listed as a game-time decision with a shoulder injury suffered against LSU, and head coach Pete Golding said Tuesday that X-rays were negative.

SEC West Reboot: LSU (No. 10) vs Texas A&M (No. 23)

Both programs enter Week 4 with something to prove. LSU (2-1) dropped three spots after its Oxford loss and hosts Texas A&M (2-1) at 7:30 p.m. ET. The Aggies fell 14 spots in the poll following their home loss to Kentucky, and the two-loss conference opener carries obvious division implications.

Georgia (No. 2) vs Oklahoma

Georgia (3-0) hosts Oklahoma (2-1) at 3:30 p.m. ET in the poll's heavyweight test. The Sooners sit behind Tennessee and Utah in the current Big 12 pecking order and need a result against a top-two team to stay relevant in the playoff conversation.

USC (No. 12) vs Oregon (No. 20)

USC (4-0) is the only undefeated team outside the top three and hosts Oregon at 7:30 p.m. ET. The Ducks have won two straight by double digits but remain unconvincing to voters after an 84-0 result over FCS Portland State.

Big Ten Test: Ohio State (No. 7) at Illinois (No. 19)

Ohio State (2-1) opens conference play at noon ET against Illinois, a genuine first test: the Fighting Illini are 3-0 and sit at No. 19, and the Buckeyes have not been convincing against top-tier competition since their loss to Texas.

Other Games Worth Watching

Alabama (No. 8) vs South Carolina (7 p.m. ET): The Crimson Tide look to build on their climb to No. 8 after a 50-36 win over Florida State.

Texas Tech (No. 11) vs Sam Houston (noon ET): The Red Raiders open as significant favorites in their first game since a 28-26 thriller over Houston.

Baylor vs Colorado (noon ET): Deion Sanders' Buffaloes begin Big 12 play after confirming that several players were dismissed from the team following a 41-7 loss at Northwestern.

Michigan (No. 18) vs Iowa (No. 17) (3:30 p.m. ET): A top-20 internal Big Ten contest in Iowa City, with Michigan's quarterback facing the Hawkeyes' zone defense.

Kentucky vs South Alabama (12:45 p.m. ET): The Wildcats try to carry momentum from their upset at Texas A&M into a favorable nonconference matchup.

What This Means for CFB 27

Three of Week 4's marquee cards translate directly into Dynasty decision points. Florida-Ole Miss and LSU-Texas A&M are both road-versus-home tests, and CFB 27 models travel and crowd factors through morale and fatigue rather than a flat modifier — which is why scheduling a tough road league game immediately after a physical nonconference win is a genuine risk.

USC-Oregon is the useful film session for anyone running a rebuild. Lincoln Riley's Trojans are 4-0 against a weaker schedule, and the game's committee rewards the résumé, so a win here is worth substantially more than a fourth blowout. In Dynasty, that is the week to change your offensive identity rather than repeat what got you here.

For Road to Glory, the Ohio State at Illinois matchup is the template for a season-defining moment at quarterback. Conference openers against a top-20 opponent are where the game's scouting flags get raised or lowered, and playing conservatively in Week 4 tends to cost you the Heisman race by November.